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CAS RN: 144060-53-7 | 产品编码: F0847
Febuxostat
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| 产品编码 | F0847 |
| 纯度/分析方法 | >97.0%(T)(HPLC) |
| 分子式/分子量 | C__1__6H__1__6N__2O__3S = 316.38 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 144060-53-7 |
| Reaxys-RN | 8005333 |
| PubChem物质ID | 172089002 |
| Merck Index (14) | 3948 |
| MDL编号 | MFCD00871598 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 207.0 to 211.0 °C |
物性（参考值）
| 熔点 | 209 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
相关法规
| RTECS# | XJ3675310 |
运输信息
| HS编码* | 2934.10-000 |
应用
Studies on the Inhibition of Xanthine Oxidoreductase, Febuxostat
References
- An Extremely Potent Inhibitor of Xanthine Oxidoreductase
- Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
- Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents
- Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome
应用
Febuxostat: A Non-Purine Selective Xanthine Oxidase (XO) Inhibitor
Febuxostat (TEI-6720) is a non-purine selective xanthine oxidase (XO) inhibitor. Uric acid [U0018] is the end product of purine metabolism in humans and is generated in the cascade of hypoxanthine [H0311] → xanthine [X0004] → uric acid. The both transformations are catalyzed by XO. Febuxostat is a XO inhibitor that significantly reduces uric acid levels in blood and urine. Therefore, in clinical, febuxostat is used for the treatment of hyperuricemia and gout. For your reference, [E1049] [E1394] and [E1414] are synthetic intermediates of febuxostat. (The product is for research purpose only.)
References
- An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition
- Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
- Febuxostat: a selective xanthine oxidase inhibitor for the treatment of hyperuricemia and gout (a review)
- Quantification of uric acid, xanthine and hypoxanthine in human serum by HPLC for pharmacodynamic studies
- Development and Validation of a Stability-Indicating RP-HPLC Method for the Determination of Febuxostat (a Xanthine Oxidase Inhibitor)
参考文献
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