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CAS RN: 104227-87-4 | 产品编码: F0842
Famciclovir
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 500MG |
S$105.00
|
11 | 2 | 下单后约2周内可以发货 |
|
补充产品信息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | F0842 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__4H__1__9N__5O__4 = 321.34 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 500MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 104227-87-4 |
| Reaxys-RN | 4208403 |
| PubChem物质ID | 160871205 |
| MDL编号 | MFCD00866964 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 103.0 to 107.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 105 °C |
| 最大吸收波长 | 310(EtOH) nm |
| 水溶性 | 微溶 |
| 溶解性（可溶于） | 乙醇, 甲醇 |
GHS
相关法规
| RTECS# | TY3164000 |
运输信息
| HS编码* | 2933.99-000 |
应用
Famciclovir: A Prodrug of Penciclovir
Famciclovir is a prodrug of penciclovir [P2164] which is an anti-herpesvirus agent. It has demonstrated inhibitory activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and varicella zoster virus (VZV). The viral thymidine kinase (TK) phosphorylates penciclovir to a monophosphate form. Subsequently, the monophosphate s converted to penciclovir triphosphate by cellular kinases. The triphosphate inhibits virus DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, famciclovir interfere with herpes viral DNA synthesis and replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to famciclovir (penciclovir), which has extremely low toxicity for human cell. (The product is for research purpose only.)
References
- Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus
- Inhibition of varicella-zoster virus by penciclovir in cell culture and mechanism of action
- In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver
- Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective
- In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance
应用
Studies on the Antiviral Activities of Famciclovir
Famciclovir is a prodrug of penciclovir [P2164] which is an anti-herpesvirus agent. It has demonstrated inhibitory activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and varicella zoster virus (VZV). The viral thymidine kinase (TK) phosphorylates penciclovir to a monophosphate form. Subsequently, the monophosphate s converted to penciclovir triphosphate by cellular kinases. The triphosphate inhibits virus DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, famciclovir interfere with herpes viral DNA synthesis and replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to famciclovir (penciclovir), which has extremely low toxicity for human cell. (The product is for research purpose only.)
References
- Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus
- Inhibition of varicella-zoster virus by penciclovir in cell culture and mechanism of action
- In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver
- Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective
- In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance
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