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CAS RN: 75507-68-5 | 产品编码: F0736
Flupirtine Maleate Salt
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| 产品编码 | F0736 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__5H__1__7FN__4O__2·C__4H__4O__4 = 420.40 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 75507-68-5 |
| 相关CAS RN | 56995-20-1 |
| Reaxys-RN | 6467047 |
| PubChem物质ID | 125307841 |
| Merck Index (14) | 4190 |
| MDL编号 | MFCD00941415 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 177 °C |
| 最大吸收波长 | 343 nm (CH__3CN) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | EY8555800 |
运输信息
| HS编码* | 2933.39-000 |
应用
Flupirtine Maleate: An Aminopyridine Potassium Kv7 (KCNQ) Channel Opener
Flupirtine maleate is an aminopyridine potassium Kv7 (KCNQ) channel opener. Flupirtine maleate also acts as N-methyl-D-aspartate (NMDA) receptor antagonist. Flupirtine maleate acts as a non-opioid centrally acting analgesic agent with muscle tone-reducing activity by reducing the excessive electrical activity that leads to pain states. (The product is for research purpose only.)
References
- Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension
- Neural KCNQ (Kv7) channels (a review)
- Flupirtine in pain management: pharmacological properties and clinical use (a review)
- Flupirtine, a re-discovered drug, revisited (a review)
- Isolation, identification and characterization of novel process-related impurities in flupirtine maleate
参考文献
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