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CAS RN: 21679-14-1 | 产品编码: F0658
Fludarabine
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| 产品编码 | F0658 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__0H__1__2FN__5O__4 = 285.24 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 21679-14-1 |
| Reaxys-RN | 1225932 |
| PubChem物质ID | 468591803 |
| Merck Index (14) | 4126 |
| MDL编号 | MFCD00132942 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +12.0 to +18.0 deg(C=0.1, ethanol) |
物性（参考值）
| 熔点 | 260 °C |
| 比旋光度 [α]D | 18° (C=0.1,EtOH) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | AU6207000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Fludarabine (F-ara-A): An Antimetabolite Antineoplastic Nucleoside
Fludarabine (F-ara-A), an antimetabolite antineoplastic nucleoside, is a 2-fluorinated nucleoside analog of the antiviral agent vidarabine (ara-A) [V0098] that is relatively resistant to deamination by adenosine deaminase. F-ara-A is rapidly phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP (F-ara-ATP). The active metabolite acts by inhibiting DNA and RNA polymerases thus preventing DNA and RNA syntheses in proliferating cells. In clinical, its monophosphate, F-ara-AMP, is used for the treatment of chronic lymphocytic leukemia (CLL) and B-cell non-Hodgkin's lymphoma. (The product is for research purpose only.)
References
- Termination of DNA synthesis by 9-β-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity
- Fludarabine: pharmacokinetics, mechanisms of action, and rationales for combination therapies (a review)
- Cellular and clinical pharmacology of fludarabine (a review)
- Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity
- A highly sensitive high-performance liquid chromatography-mass spectrometry method for quantification of fludarabine triphosphate in leukemic cells
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