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CAS RN: 51-21-8 | 产品编码: F0151
5-Fluorouracil
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Neutralization titration) | min. 99.0 % |
| Solubility in hot Water | almost transparency |
物性（参考值）
| 熔点 | 283 °C(dec.) |
| 水溶性 | 微溶 |
| 溶解性（可溶于） | 二甲基甲酰胺 |
| 溶解性（微溶于） | 甲醇 |
| 溶解性（不溶于） | 氯仿, 苯, 乙醚 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | YR0350000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2933.59-000 |
应用
Quorum sensing research / Biofilm research
References
- 5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice
- The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors
- 5-Fluorouracil reduces biofilm formation in Escherichia coli K-12 through global regulator AriR as an antivirulence compound
- Uracil influences quorum sensing and biofilm formation in Pseudomonas aeruginosa and fluorouracil is an antagonist
应用
5-Fluorouracil (5-FU): An Antitumor Antimetabolite with Activity against Numerous Types of Neoplasms
5-Fluorouracil (5-FU) is an antitumor antimetabolite with activity against numerous types of neoplasms. Further, many prodrugs of 5-FU have been developed to increased plasma and tumor 5-FU concentrations and to improve the cytotoxicity, such as capecitabine [C2878], doxifluridine [D3579], carmofur [C2663], tegaful [F0635], UFT (tegafur and uracil [U0013]) and S-1 (tegafur, gimeracil [C2243] and potassium oxonate [O0164]). (The product is for research purpose only.)
References
- Fluorouracil: biochemistry and pharmacology (a review)
- 5-Fluorouracil: mechanisms of action and clinical strategies (a review)
- Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism (a review)
- The prodrugs of 5-fluorouracil (a review)
- Determination of 5-fluorouracil in environmental samples by solid-phase extraction and high-performance liquid chromatography with ultraviolet detection
- A review of analytical methods for the determination of 5-fluorouracil in biological matrices
应用
Reagent for gastropathy (gastric mucosal injury) model
References
- 16-16 dimethyl prostaglandin E2 reduces 5-fluorouracil-induced and mitomycin C-induced gastric mucosal injury in the dog
- Effects of acid antisecretory drugs on mucus barrier of the rat against 5-fluorouracil-induced gastrointestinal mucositis
应用
Reagent for nausea or vomiting model
Reference
- The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential
参考文献
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