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CAS RN: 202409-33-4 | 产品编码: E1492
Etoricoxib
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纯度/分析方法: >95.0%(T)(HPLC)
别名：
- 依托考昔
- 5-氯-6′-甲基-3-[4-(甲基磺酰基)苯基]-2,3′-联吡啶
- 5-氯-3-[4-(甲基磺酰基)苯基]-2-(2-甲基-5-吡啶基)吡啶
- 5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine
- 5-Chloro-3-[4-(methylsulfonyl)phenyl]-2-(2-methyl-5-pyridinyl)pyridine
产品文档：
| 产品编码 | E1492 |
| 纯度/分析方法 | >95.0%(T)(HPLC) |
| 分子式/分子量 | C__1__8H__1__5ClN__2O__2S = 358.84 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 202409-33-4 |
| Reaxys-RN | 8073797 |
| MDL编号 | MFCD06797512 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Melting point | 133.0 to 137.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 135 °C |
GHS
相关法规
| RTECS# | DW1762210 |
运输信息
| HS编码* | 2933.39-000 |
应用
Etoricoxib: A Selective Cyclooxygenase-2 (COX-2) Inhibitor
Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID), and a selective inhibitor of COX-2 (cyclooxygenase 2) with a higher COX-1 to COX-2 selectivity ratio than the other COX-2-selective inhibitors, such as rofecoxib [R0206], valdecoxib [V0133] or celecoxib [C2816]. The mechanism of action is mainly by inhibition of the enzyme COX in the arachidonic acid metabolism pathway, resulting in reduced prostaglandin synthesis. In theory, a drug that selectively inhibited COX-2 might block inflammation, pain, and fever produced by prostaglandins while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1. (The product is for research purpose only.)
References
- Etoricoxib (a review)
- Selective COX-2 inhibitors: a review of their structure-activity relationships (a review)
- RP-HPLC method for simultaneous estimation of Paracetamol and Etoricoxib from bulk and tablets
- Determination of etoricoxib in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionisation
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