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CAS RN: 236395-14-5 | 产品编码: E1046
Eslicarbazepine Acetate
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| 产品编码 | E1046 |
| 纯度/分析方法 | >98.0%(HPLC)(N) |
| 分子式/分子量 | C__1__7H__1__6N__2O__3 = 296.33 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 236395-14-5 |
| Reaxys-RN | 8336447 |
| PubChem物质ID | 253662249 |
| MDL编号 | MFCD06798333 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 185.0 to 189.0 °C |
| Specific rotation [a]20/D | -20.0 to -24.0 deg(C=1, Pyridine) |
物性（参考值）
| 熔点 | 187 °C |
| 比旋光度 [α]D | -22° (C=1,Pyridine) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H336 : May cause drowsiness or dizziness. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P271 : Use only outdoors or in a well-ventilated area. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
Romifidine: a potent and selective α2-adrenoceptor agonist
Eslicarbazepine acetate (BIA 2-093 or ESL) is a central nervous system (CNS)-active compound with anticonvulsant activity. BIA 2-093 has voltage-gated sodium channel (VGSC) blocking property. BIA 2-093 is metabolized to eslicarbazepine (S-licarbazepine), an active metabolite of oxcarbazepine [O0363], which is responsible for pharmacological activity. BIA 2-093 is used as a third generation antiepileptic drugs (AEDs), and is often used in combination with the other AEDs. (The product is for research purpose only.)
References
- Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives
- Metabolism of two new antiepileptic drugs and their principal metabolites S(+)- and R(-)-10,11-dihydro-10-hydroxy carbamazepine
- Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma
- Eslicarbazepine acetate (BIA 2-093) (a review)
- Drug interactions involving the new second- and third-generation antiepileptic drugs (a review)
参考文献
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