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CAS RN: 33419-42-0 | 产品编码: E0675
Etoposide
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| 产品编码 | E0675 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__9H__3__2O__1__3 = 588.56 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 应避免的情况 | 光 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 33419-42-0 |
| Reaxys-RN | 365969 |
| PubChem物质ID | 87558799 |
| Merck Index (14) | 3886 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Water | max. 7.0 % |
物性（参考值）
| 熔点 | 251 °C |
| 溶解性（微溶于） | 乙醇 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H371 : May cause damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H350 : May cause cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | KC0190000 |
运输信息
| HS编码* | 2938.90-000 |
应用
Adeno-associated virus vector transduction enhancer
Etoposide exhibits enhancement of adeno-associated virus transduction.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
应用
Etoposide: A Topoisomerase-II Inhibitor
Etoposide (VP 16) is a semisynthetic antitumor alkaloid which is synthesized form podophyllotoxin [P1771] , a toxin found in the American Mayapple. Etoposide interferes with DNA synthesis by inhibiting the enzyme topoisomerase-II. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-II catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action leads to cell cycle arrest at G2/M, apoptosis or cell death. Bacterial type II topoisomerases (DNA gyrase and Topoisomerase-IV) are the targets of quinolone antibiotics.
References
- Etoposide: four decades of development of a topoisomerase II inhibitor(a review)
- Etoposide, topoisomerase II and cancer(a review)
- Plants as a source of anti-cancer agents(a review)
- DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs(a review)
参考文献
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