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CAS RN: 211915-06-9 | 产品编码: D5904
Dabigatran Etexilate
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 达比加群酯
- N-[[2-[[4-[N-[(己氧基)羰基]甲脒基]苯胺基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-β-丙氨酸乙酯
- 3-[2-[[[4-[N-[(己氧基)羰基]甲脒基]苯基]氨基]甲基]-1-甲基-N-(吡啶-2-基)-1H-苯并[d]咪唑-5-甲酰氨基]丙酸乙酯
- Ethyl N-[[2-[[4-[N-[(Hexyloxy)carbonyl]carbamimidoyl]anilino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alaninate
- Ethyl 3-[2-[[[4-[N-[(Hexyloxy)carbonyl]carbamimidoyl]phenyl]amino]methyl]-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido]propanoate
产品文档：
| 产品编码 | D5904 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__3__4H__4__1N__7O__5 = 627.75 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 211915-06-9 |
| Reaxys-RN | 10137269 |
| PubChem物质ID | 468591633 |
| MDL编号 | MFCD22422841 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 129.0 to 133.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 131 °C |
GHS
相关法规
运输信息
| HS编码* | 2933.39-000 |
应用
Dabigatran Etexilate: An Oral, Reversible Direct Thrombin Inhibitor
Dabigatran etexilate is an oral, reversible direct thrombin inhibitor, and a prodrug of dabigatran [D5902]. Thrombin enables the conversion of fibrinogen into fibrin during the blood coagulation cascade. The inhibition prevents the development of a thrombus. Therefore, thrombin-induced platelet aggregation are inhibited by the active metabolite, dabigatran. In clinical, it is used as an alternative to warfarin [W0005] and does not require monitoring of blood coagulation parameters by blood tests. (The product is for research purpose only.)
References
- Advancement in antithrombotics for stroke prevention in atrial fibrillation (a review)
- Dabigatran etexilate - a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity (a review)
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