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CAS RN: 62013-04-1 | 产品编码: D5495
Dirithromycin
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| 产品编码 | D5495 |
| 纯度/分析方法 | >98.0%(HPLC)(N) |
| 分子式/分子量 | C__4__2H__7__8N__2O__1__4 = 835.09 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 62013-04-1 |
| Reaxys-RN | 6842524 |
| PubChem物质ID | 468591372 |
| Merck Index (14) | 3354 |
| MDL编号 | MFCD00865041 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 186.0 to 190.0 °C |
| Specific rotation [a]20/D | -85.0 to -90.0 deg(C=1, MeOH) |
物性（参考值）
| 熔点 | 188 °C |
| 比旋光度 [α]D | -88° (C=1,MeOH) |
GHS
相关法规
| RTECS# | JG5806477 |
运输信息
| HS编码* | 2941.50-000 |
应用
Dirithromycin: A Macrolide Antibiotic with Outstanding Activity against Campylobacter
Dirithromycin is a macrolide antibiotic derived from erythromycin [E0751]. Dirithromycin is a prodrug, and is hydrolyzed in vivo to its major active metabolite, erythromycilamine.1) Although the antimicrobial spectrum of dirithromycin is similar to that of erythromycin, it reportedly has outstanding activity against Campylobacter.2) In addition, erythromycin inhibits cytochrome P450 isoform 3A4 (CYP3A4), but dirithromycin and azithromycin [A2076] neither inhibit CYP3A4 nor are implicated in clinically significant drug-drug interactions.3) (The product is for research purpose only.)
References
- 1) Synthesis and antimicrobial evaluation of dirithromycin (ASE 136; LY237216), a new macrolide antibiotic derived from erythromycin
- 2) Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides
- 3) Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin (a review)
- 4) Analysis of macrolide antibiotics (a review)
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