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CAS RN: 4143-62-8 | 产品编码: D4794
3',4'-Dimethoxyflavone

产品编码 | D4794 |
纯度/分析方法 | >98.0%(GC) |
分子式/分子量 | C__1__7H__1__4O__4 = 282.30 |
外观与形状(20°C) | 固体 |
储存温度 | 室温 (15°C以下阴凉干燥处) |
包装和容器 | 200MG-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 4143-62-8 |
Reaxys-RN | 236749 |
PubChem物质ID | 354333484 |
MDL编号 | MFCD00143009 |
技术规格
Appearance | White to Light yellow powder to crystal |
Purity(GC) | min. 98.0 % |
Melting point | 151.0 to 155.0 °C |
NMR | confirm to structure |
物性(参考值)
熔点 | 153 °C |
最大吸收波长 | 334 nm (MeOH) |
GHS
相关法规
RTECS# | DJ3012950 |
运输信息
HS编码* | 2932.99-000 |
应用
3',4'-Dimethoxyflavone: An Inhibitor of Poly (ADP-Ribose) Polymerase (PARP) Enzymes
Genomic instability is a hallmark of cancer and is often the result of altered DNA repair capabilities in tumor cells. Poly (ADP-ribose) polymerases (PARPs) are enzymes responsible for DNA damage detection and repair factor recruitment. PARP inhibitors are able to interact with the binding site for the PARP cofactor NAD+ and trap PARP on DNA, and induce cell death through replication stress-induced mitotic catastrophe. It has been reported that 3',4'-dimethoxyflavone is a PARP inhibitor and has neuroprotective effects. (The product is for research use only.)
Reference
- Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos
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