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CAS RN: 979-02-2 | 产品编码: D4687
16-Dehydropregnenolone Acetate
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| 产品编码 | D4687 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__3H__3__2O__3 = 356.51 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| CAS RN | 979-02-2 |
| Reaxys-RN | 4712779 |
| MDL编号 | MFCD00051130 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 172.0 to 176.0 °C |
| Specific rotation [a]20/D | -38.0 to -42.0 deg(C=1,CHCl3) |
物性（参考值）
| 熔点 | 174 °C |
| 比旋光度 [α]D | -40° (C=1,CHCl3) |
| 最大吸收波长 | 269(EtOH) nm |
GHS
相关法规
| RTECS# | TU4156200 |
运输信息
| HS编码* | 2937.29-000 |
应用
16-Dehydropregnenolone acetate (16-DPA): A Versatile Building Block for Preparation of Steroidal Pharmacophores
16-Dehydropregnenolone acetate (16-DPA) is an important intermediate for preparation of dexamethasone [D1961], betamethasone [B1837], 5α-reductase inhibitors (such as finasteride [F0675]), and related other steroidal pharmacophores.
References
- Chemistry of ayurvedic crude drugs. V. Guggulu (resin from Commiphora mukul). 5 some new steroidal components and stereochemistry of guggulsterol-I at C-20 and C-22
- Synthesis and in vitro activity of some epimeric 20α-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17α-hydroxylase/C17,20-lyase and 5α-reductase
- Evaluation of new pregnane derivatives as 5α-reductase inhibitor
- New 5α-reductase inhibitors: In vitro and in vivo effects
- A Lactosylated Steroid Contributes in Vivo Therapeutic Benefits in Experimental Models of Mouse Lymphoma and Human Glioblastoma
