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CAS RN: 1229-29-4 | 产品编码: D4626
Doxepin Hydrochloride (mixture of isomers)
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| 产品编码 | D4626 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__9H__2__1NO·HCl = 315.84 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 1229-29-4 |
| 相关CAS RN | 1668-19-5 |
| Reaxys-RN | 5463221 |
| PubChem物质ID | 253662533 |
| Merck Index (14) | 3435 |
| MDL编号 | MFCD00079135 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of isomers) |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 186.0 to 190.0 °C |
物性（参考值）
| 熔点 | 188 °C |
| 最大吸收波长 | 298 nm |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | HQ4375000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2932.99-000 |
应用
Doxepin Hydrochloride: A Monoamine Reuptake Inhibitor with a Wide Range of Pharmacological Properties
Doxepin hydrochloride has a wide range of pharmacological properties including an antinoradrenergic property. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H1 and H2 receptors. Doxepin hydrochloride is a family of tricyclic antidepressant agents such as amitriptyline hydrochloride [A0908] and imipramine hydrochloride. (The product is for research purpose only.)
References
- Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression
- Tricyclic antidepressants as long-acting local anesthetics
- Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin
- Structure of the human histamine H1 receptor complex with doxepin
- Spectrofluorimetric method for the determination of doxepin hydrochloride in commercial dosage forms
参考文献
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