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CAS RN: 120011-70-3 | 产品编码: D4099
Donepezil Hydrochloride
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| 产品编码 | D4099 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__4H__2__9NO__3·HCl = 415.96 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 120011-70-3 |
| 相关CAS RN | 120014-06-4 |
| Reaxys-RN | 7062905 |
| PubChem物质ID | 160870963 |
| Merck Index (14) | 3419 |
| MDL编号 | MFCD17215939 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 225 °C |
| 水溶性 | 可溶 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H300 : Fatal if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | NK8927885 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | II |
| HS编码* | 2933.39-000 |
应用
Donepezil Hydrochloride: A Reversible Inhibitor of the Enzyme Acetylcholinesterase (AChE).
Donepezil hydrochloride (E2020) is a reversible inhibitor of the enzyme acetylcholinesterase (AChE). Donepezil activates central cholinergic nervous system by increasing the concentration of acetylcholine (ACh) in brain through reversible inhibition of its hydrolysis by acetylcholinesterase. Donepezil hydrochloride is used for the treatment of Alzheimer’s disease. (The product is for research purpose only.)
References
- Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs
- Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors: 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine Hydrochloride and Related Compounds
- Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors (a review)
- Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor (a review)
- The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor
- A new HPLC method to determine Donepezil hydrochloride in tablets
- Determination of donepezil, an acetylcholinesterase inhibitor, in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection
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