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CAS RN: 41100-52-1 | 产品编码: D3608
3,5-Dimethyl-1-adamantanamine Hydrochloride
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Purity(Argentometric Titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 292 °C |
| 水溶性 | 可溶 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2921.30-000 |
应用
Memantine Hydrochloride: A Moderate-Affinity and Uncompetitive N-Methyl-D-Aspartate (NMDA) Receptor Antagonist
Memantine hydrochloride is a moderate-affinity and uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. NMDA receptor (NMDAR) is a subtype of glutamate receptor, and very important for controlling synaptic plasticity and memory function. Persistent activation of central nervous system NMDAR by the excitatory amino acid glutamate has been hypothesized to contribute to the symptomatology of Alzheimer’s disease. Memantine binds preferentially in moderate to the NMDAR-operated cation channels, blocks current flow through the NMDARs, and controls the activity of the NMDARs. Therefore, memantine is used for the treatment of Alzheimer’s disease. (The product is for research purpose only.)
References
- Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity
- Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist-a review of preclinical data (a review)
- Mechanism of action of Memantine (a review)
- N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease (a review)
- Fluorimetric liquid chromatographic analysis of amantadine in urine and pharmaceutical formulation
- Simultaneous liquid chromatographic assay of amantadine and its four related compounds in phosphate-buffered saline using 4-fluoro-7-nitro-2,1,3-benzoxadiazole [A5593] as a fluorescent derivatization reagent
参考文献
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