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CAS RN: 3094-09-5 | 产品编码: D3579
5'-Deoxy-5-fluorouridine
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| 产品编码 | D3579 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__9H__1__1FN__2O__5 = 246.19 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 3094-09-5 |
| Reaxys-RN | 890191 |
| PubChem物质ID | 87559877 |
| Merck Index (14) | 3437 |
| MDL编号 | MFCD00866530 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 189.0 to 193.0 °C |
| Specific rotation [a]20/D | +18.0 to +22.0 deg(C=1, H2O) |
物性（参考值）
| 熔点 | 189 °C |
| 比旋光度 [α]D | 20° (C=1,H2O) |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H373 : May cause damage to organs through prolonged or repeated exposure. H317 : May cause an allergic skin reaction. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P272 : Contaminated work clothing should not be allowed out of the workplace. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P314 : Get medical advice/ attention if you feel unwell. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
相关法规
| RTECS# | YU7526000 |
运输信息
| HS编码* | 2934.99-000 |
应用
5'-Deoxy-5-Fluorouridine (Doxifluridine): A Prodrug of Active Antitumor 5-FU
5'-Deoxy-5-fluorouridine (doxifluridine) is a prodrug of active antitumor 5-FU [F0151] and an intermediary metabolite of capecitabine [C2878] and 5'-deoxy-5-fluorocytidine [D4342]. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine and doxifluridine, to form 5-FU. Capecitabine and its intermediary metabolites are not cytotoxic by themselves. The final step (doxifluridine to 5-FU) requires thymidine phosphorylase (dThdPase) that is significantly more active in tumor than normal tissue. This tumor-selective delivery of 5-FU ensured greater efficacy and a more favorable safety profile than with other fluoropyrimidines. (The product is for research purpose only.)
References
- Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5'-deoxy-5-fluorouridine
- Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumors by enzymes concentrated in human liver and cancer tissue
- Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts
- Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5'-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models
- Thymidine phosphorylase and fluoropyrimidines efficacy: a Jekyl and Hyde story (a review)
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