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CAS RN: 4205-91-8 | 产品编码: D1353
Clonidine Hydrochloride
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产品编码 | D1353 |
纯度/分析方法 | >98.0%(T)(HPLC) |
分子式/分子量 | C__9H__9Cl__2N__3·HCl = 266.55 |
外观与形状(20°C) | 固体 |
储存温度 | 室温 (15°C以下阴凉干燥处) |
应避免的情况 | 光 |
包装和容器 | 1G-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 4205-91-8 |
相关CAS RN | 4205-90-7 |
Reaxys-RN | 4163525 |
PubChem物质ID | 87567869 |
Merck Index (14) | 2390 |
MDL编号 | MFCD00036705 |
技术规格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
NMR | confirm to structure |
物性(参考值)
熔点 | 312 °C |
水溶性 | 可溶 |
溶解性(可溶于) | 乙醇 |
溶解性(微溶于) | 氯仿 |
溶解性(不溶于) | 乙醚 |
GHS
象形图 |
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信号词 | Danger |
危险性说明 | H330 : Fatal if inhaled. H301 : Toxic if swallowed. |
防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P284 : Wear respiratory protection. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相关法规
RTECS# | NJ2490000 |
运输信息
UN编号 | UN2811 |
类别 | 6.1 |
包装类别 | I |
HS编码* | 2933.29-000 |
应用
Clonidine Hydrochloride: An α2-Adrenoceptor Agonist
Clonidine hydrochloride, an imidazoline derivative, is an α2-adrenoceptor agonist such as dexmedetomidine hydrochloride [D5062], guanfacine hydrochloride [G0414], moxonidine [M2660] and et al. Clonidine stimulates α2-adrenoceptor in the brain stem, and suppresses sympathetic outflow and decreases vascular resistance resulting in lower blood pressure. (The product is for research purpose only.)
References
- Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidineLysicamine, and Alkaloid PO-3
- α2-Adrenoceptor-mediated hyperpolarization of locus ceruleus neurons: intracellular studies in vivo
- Central blood pressure regulation: involvement of presynaptic or postsynaptic, α1- or α2-adrenoceptors?
- Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla
- Imidazoline antihypertensive drugs: a critical review on their mechanism of action (a review)
- Clonidine hydrochloride (a review on preparation, properties, analysis, and pharmacology)
参考文献
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