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CAS RN: 892-48-8 | 产品编码: C3773
5'-Chloro-5'-deoxyadenosine
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| 产品编码 | C3773 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__0H__1__2ClN__5O__3 = 285.69 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气 |
| CAS RN | 892-48-8 |
| Reaxys-RN | 624885 |
| MDL编号 | MFCD03427103 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 187 °C |
GHS
相关法规
| RTECS# | AU7357200 |
运输信息
| HS编码* | 2934.99-000 |
应用
5'-Chloro-5'-deoxyadenosine: A Nucleoside Analog Used as a Substrate in Polyketide Biosynthesis
Incorporating a halogen atom into a scaffold of bioactive compounds often enhances biological activity, as in the case of the anticancer agent marizomib (salinosporamide A, a polyketide), a natural product with potent 20S proteasome inhibitory activity isolated from the marine microorganism Salinispora tropica. 5'-Chloro-5'-deoxyadenosine is a nucleoside analog used as a substrate in polyketide biosynthesis. S-adenosyl-L-methionine (SAM) is converted to 5'-chloro-5'-deoxyadenosine in a reaction catalyzed by SAM-dependent chlorinase. Through a 7-step route, 5'-chloro-5'-deoxyadenosine is converted to chloroethylmalonyl-CoA, which is involved in the biosynthesis of marizomib.
References
- Discovery and characterization of a marine bacterial SAM-dependent chlorinase
- Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine
- Preparation, assay, and application of chlorinase SalL for the chemoenzymatic synthesis of S-Adenosyl-L-methionine and analogs
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