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CAS RN: 6020-18-4 | 产品编码: C3719
Coptisine Chloride
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纯度/分析方法: >95.0%(T)(HPLC)
别名：
- 氯化黄连碱
- 7,8,13,13a-四脱氢-2,3:9,10-双(亚甲基二氧基)氯化小檗碱
- 6,7-二氢双[1,3]苯并二氧戊环并[5,6-a:4',5'-g]氯化喹嗪
- 6,7-二氢-[1,3]二氧戊环并[4',5':7,8]异喹啉并[3,2-a][1,3]二氧戊环并[4,5-g]异喹啉-5-鎓氯化物
- 7,8,13,13a-Tetradehydro-2,3:9,10-bis(methylenedioxy)berbinium Chloride
- 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium Chloride
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产品文档：
| 产品编码 | C3719 |
| 纯度/分析方法 | >95.0%(T)(HPLC) |
| 分子式/分子量 | C__1__9H__1__4NO__4Cl = 355.77 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,湿气 (吸湿) |
| CAS RN | 6020-18-4 |
| Reaxys-RN | 4118452 |
| MDL编号 | MFCD00016676 |
技术规格
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Precipitation Titration) | min. 95.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 218 °C |
GHS
相关法规
运输信息
| HS编码* | 2939.79-000 |
应用
Coptisine Chloride: A Protoberberine Alkaloid with a Wide Range of Pharmacological and Biological Activities
Coptisine chloride, a protoberberine alkaloid, is widely found in traditional Chinese medicinal plants including Coptis rhizome, Ranunculaceae and Papaveraceae plants. There are reports that coptisine chloride has a wide range of pharmacological and biological activities.1-3) Recently, coptisine chloride has also been attracting attention on its activity against central nervous system disorders, such as improving the symptoms of Alzheimer’s disease.4) (The product is for research purpose only.)
References
- 1) Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth
- 2) Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in
- 3) Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation
- 4) Anti-alzheimer and antioxidant activities of coptidis Rhizoma alkaloids
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