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CAS RN: 298-57-7 | 产品编码: C3459
Cinnarizine
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 117.0 to 121.0 °C |
物性（参考值）
| 熔点 | 119 °C |
GHS
相关法规
运输信息
| HS编码* | 2933.59-000 |
应用
Cinnarizine: A Calcium Channel and a Histamine H1 Receptor Antagonist
Cinnarizine, a piperazine derivative, is a calcium channel and a histamine H1 receptor antagonist. Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking calcium channels. In addition, cinnarizine increases erythrocyte deformability and decreases blood viscosity. Cinnarizine also exhibits anticonvulsant properties. Cinnarizine is used widely in the treatment of circulatory disorders. However, cinnarizine-induced parkinsonism has been reported. (The product is for research purpose only.)
References
- Flunarizine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use
- Effects of cinnarizine, a calcium antagonist that produces human parkinsonism, in parkin knock out mice
- Oral bioavailability of cinnarizine in dogs: Relation to SNEDDS droplet size, drug solubility and in vitro precipitation
- Simultaneous determination of cinnarizine and domepiridone maleate from tablet dosage form by reverse phase ion pair high performance liquid chromatography
- Validation of a solid-phase extraction and liquid chromatography-electrospray tandem mass spectrometric method for the determination of nine basic pharmaceuticals in wastewater and surface water samples
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