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CAS RN: 1003845-08-6 | 产品编码: C3436
2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
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纯度/分析方法: >98.0%(GC)(T)
别名：
- 2-氯-5-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)嘧啶
- 2-(5-氯-2-嘧啶基)-4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷
- 2-氯嘧啶-5-硼酸频哪醇酯
- 2-(5-Chloro-2-pyrimidyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- 2-Chloropyrimidine-5-boronic Acid Pinacol Ester
产品文档：
| 产品编码 | C3436 |
| 纯度/分析方法 | >98.0%(GC)(T) |
| 分子式/分子量 | C__1__0H__1__4BClN__2O__2 = 240.49 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 1003845-08-6 |
| Reaxys-RN | 15622160 |
| PubChem物质ID | 354334441 |
| MDL编号 | MFCD11856048 |
技术规格
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 65.0 to 69.0 °C |
物性（参考值）
| 熔点 | 68 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
A Synthetic Intermediate of Imidazole Derivatives as Modulators of TNFα Activity
This product is used for the synthesis of imidazole derivatives as modulators of TNFα activity.
References
- Benzimidazles as TNF-alpha modulators and their preparation
- D. C. Brookings, M. D. Calmiano, E. O. Gallimore, H. T. Horsley, M. C. Hutchings, J. A. Johnson, B. Kroeplien, F. C. Lecomte, M. A. Lowe, T. J. Norman, J. R. Porter, J. R. Quincey, J. T. Reuberson, M. D. Selby, M. A. Shaw, Z. Zhu, A. M. Foley, WO/2013/186229.
- Imidazopyridine derivatives as modulators of TNF activity and their preparation
- J. M. Bentley, D. C. Brookings, J. A. Brown, T. P. Cain, P. T. Chovatia, A. M. Foley, E. O. Gallimore, L. J. Gleave, A. Heifetz, H. T. Horsley, M. C. Hutchings, V. E. Jackson, J. A. Johnson, C. Johnstone, B. Kroeplien, F. C. Lecomte, D. Leigh, M. A. Lowe, J. Madden, J. R. Porter, J. R. Quincey, L. C. Reed, J. T. Reuberson, A. J. Richardson, S. E. Richardson, M. D. Selby, M. A. Shaw, Z. Zhu, WO/2014/009295.
- Fused tricyclic imidazole derivatives as modulators of TNF activity and their preparation
- R. P. Alexander, G. N. Brace, J. A. Brown, M. D. Calmiano, P. T. Chovatia, E. O. Deligny, E. O. Gallimore, J. P. Heer, V. E. Jackson, B. Kroeplien, M. Mac Coss, J. R. Quincey, Y. A. Sabnis, D. L. L. Swinnen, Z. Zhu, V. Wehner, U. Heinelt, WO/2015/086526.
参考文献
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