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CAS RN: 118081-37-1 | 产品编码: C3391
Ceftibuten Hydrate
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纯度/分析方法: >95.0%(HPLC)
别名：
- 头孢布烯 水合物
- (6R,7R)-7-[[(2Z)-2-(2-氨基-4-噻唑基)-4-羧基-1-氧代-2-丁烯-1-基]氨基]-8-氧代-5-硫-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸 水合物
- (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-4-carboxy-1-oxo-2-buten-1-yl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Hydrate
产品文档：
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This product has not been tested for potency and is guaranteed for chemical purity.
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation [a]20/D | +135 to +155 deg(C=1, pH 8 Phosphate buffer(calcd.on anh.substance)) |
| Water | 8.0 to 13.0 % |
| NMR | confirm to structure |
物性（参考值）
| 比旋光度 [α]D | 143° (C=1,Phosphate buffer sol.) |
GHS
相关法规
| RTECS# | XI0367220 |
运输信息
| HS编码* | 2941.90-000 |
应用
Ceftibuten: A Third-Generation β-Lactamase-Stable, Broad-Spectrum Cephalosporin
Ceftibuten (7432-s) is a third-generation cephalosporin that exhibits good antimicrobial activity against many Gram-negative and some Gram-positive organisms. Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall. This binding leads to inhibition of cell-wall synthesis. Especially, ceftibuten has a greater affinity for penicillin-binding protein 3 (PBP 3) more than other cephalosporins. Ceftibuten has a carboxyethylidene substituent at the 7 position, and thereby it is stable against both β-lactamases of Gram-negative bacteria and those mediated by R plasmids. (The product is for research purpose only.)
References
- Ceftibuten - in vitro activity against respiratory pathogens, β-lactamase stability and mechanism of action
- Ceftibuten. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy
- Ceftibuten: An Overview
- Liquid chromatographic determination of ceftibuten, a new oral cephalosporin, in human plasma and urine
参考文献
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