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CAS RN: 6202-23-9 | 产品编码: C3157
Cyclobenzaprine Hydrochloride
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| 产品编码 | C3157 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__0H__2__1N·HCl = 311.85 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 6202-23-9 |
| 相关CAS RN | 303-53-7 |
| Reaxys-RN | 6247987 |
| PubChem物质ID | 253661206 |
| Merck Index (14) | 2713 |
| MDL编号 | MFCD00079039 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 215.0 to 219.0 °C |
物性（参考值）
| 熔点 | 217 °C |
| 最大吸收波长 | 290 nm |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | HP0875000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2921.49-000 |
应用
Cyclobenzaprine Hydrochloride: A Muscle Relaxant Acting on the Central Nervous System
Cyclobenzaprine hydrochloride is a muscle relaxant acting primarily on the central nervous system, and is structurally similar to tricyclic antidepressants. It works by blocking nerve impulses (or pain sensations) that are sent to the brain. The exact mechanism of action is still not clear, while a research appears to indicate that it acts as a 5-HT2 receptor antagonist.
References
- Physiological disposition and metabolism of cyclobenzaprine in the rat, dog, rhesus monkey, and man
- Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine
- Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems
- Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone (a review)
- Development and comparison of high-performance liquid chromatographic methods with tandem mass spectrometric and ultraviolet absorbance detection for the determination of cyclobenzaprine in human plasma and urine
参考文献
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