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CAS RN: 56796-39-5 | 产品编码: C3029
Cefmetazole Sodium Salt
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This product has not been tested for potency and is guaranteed for chemical purity.
| 产品编码 | C3029 |
| 纯度/分析方法 | >92.0%(HPLC) |
| 分子式/分子量 | C__1__5H__1__6N__7NaO__5S__3 = 493.51 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 56796-39-5 |
| 相关CAS RN | 56796-20-4 |
| Reaxys-RN | 5403925 |
| PubChem物质ID | 253660567 |
| Merck Index (14) | 1926 |
| MDL编号 | MFCD00214260 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 92.0 area% |
| Purity(Ion exchange titration) | min. 97.0 % |
| Specific rotation [a]20/D | +73.0 to +85.0 deg(C=1, H2O) |
物性（参考值）
| 比旋光度 [α]D | 80° (C=1,H2O) |
| 溶解性（可溶于） | 丙酮 |
| 溶解性（不溶于） | 四氢呋喃, 氯仿 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | XI0372200 |
运输信息
| HS编码* | 2941.90-000 |
应用
Cefmetazole Sodium Salt: A (7S)-Methoxy Cephalosporin (Cephamycin)
Cefmetazole sodium salt (CS-1170), a first generation of (7S)-methoxy cephalosporin (cephamycin), is chemically synthesized form 7-MAC [M2129]. The steric hindrance effect that is enhanced by introducing (7S)-methoxy into the β-lactam ring significantly increases the stability of β-lactam antibiotics against β-lactamases, and to some extent reduces the problems of bacterial drug-resistance. Cefmetazole has a broad spectrum of activity against Gram-negative and Gram-positive bacteria, and is generally more active against Gram-negative bacteria than the ‘first and second generation’ cephalosporins.
References
- Antibacterial activity of cefmetazole alone and in combination with fosfomycin against methicillin- and cephem-resistant Staphylococcus aureus
- Annual incidence, epidemiology, and comparative in vitro susceptibilities to cefoxitin, cefotetan, cefmetazole, and ceftizoxime of recent community-acquired isolates of the Bacteroides fragilis group.
- Enhanced rectal absorption of cefmetazole and cefoxitin in the presence of epinephrine metabolites in rats and a high-performance liquid chromatographic assay for cephamycin antibiotics
- Review of the in-vitro spectrum and characteristics of cefmetazole (CS-1170)
参考文献
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