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CAS RN: 168555-66-6 | 产品编码: C3009
Combretastatin A4 Phosphate Disodium Salt
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| 产品编码 | C3009 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__8H__1__9Na__2O__8P = 440.30 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| CAS RN | 168555-66-6 |
| PubChem物质ID | 354333373 |
| MDL编号 | MFCD00943911 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
物性（参考值）
GHS
相关法规
运输信息
| HS编码* | 2919.90-000 |
应用
Antitumor Compound, Combretastatin A4 Phosphate (CA4P)
Combretastatin A4 phosphate (CA4P), a water-soluble antitumor prodrug of Combretastatin A4, is converted to Combretastatin A4 by metabolism. CA4P inhibits microtubule polymerization, thereby inducing mitotic arrest and apoptosis in endothelial cells. It has been reported that CA4P has significant effects on tumor vascularization by disrupting vascular endothelial cadherin.
References
- Antineoplastic agents. 322. Synthesis of combretastatin A-4 prodrugs
- Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues
- Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling
参考文献
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