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CAS RN: 98753-19-6 | 产品编码: C3007
Cefpirome Sulfate
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This product has not been tested for potency and is guaranteed for chemical purity.
| 产品编码 | C3007 |
| 纯度/分析方法 | >95.0%(HPLC)(N) |
| 分子式/分子量 | C__2__2H__2__2N__6O__5S__2·H__2SO__4 = 612.65 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿),加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 98753-19-6 |
| 相关CAS RN | 84957-29-9 |
| Reaxys-RN | 11738005 |
| PubChem物质ID | 253661002 |
| Merck Index (14) | 1940 |
| MDL编号 | MFCD11864966 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| Specific rotation [a]20/D | -27.0 to -33.0 deg(C=2.5,a solution prepared by addition of water to 25mL of actonitrile to make 50mL)(calcd.on anh.substance) |
| Water | max. 5.0 % |
物性（参考值）
| 熔点 | 200 °C |
| 比旋光度 [α]D | -30° (C=2.5,JP Method) |
| 最大吸收波长 | 265 nm (Buffer) |
| 水溶性 | 可溶 |
| 溶解性（不溶于） | 乙醚, 乙醇 |
GHS
相关法规
| RTECS# | UW8970000 |
运输信息
| HS编码* | 2941.90-000 |
应用
Cefpirome: A Fourth Generation Cephalosporin with Broad Spectrum of Activity and Stability to β-Lactamases
Cefpirome sulfate is a fourth generation semi-synthetic cephalosporin. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally more active against Gram-negative bacteria than the first and second generation cephalosporins. While the mechanism of action similar to other cephalosporins (inhibition of peptidoglycan synthesis by cell walls), cefpirome has also activity against Gram-positive coccus (eg. Streptococcus pneumoniae) more than the third generation cephalosporins, regardless of penicillin susceptibility. And it has increased stability to β-lactamases compared with the first and second generation cephalosporins.
References
- Stability and degradation pattern of cefpirome (HR 810) in aqueous solution
- Comparative study of pharmacokinetics and serum bactericidal activities of cefpirome, ceftazidime, ceftriaxone, imipenem, and ciprofloxacin
- Cefpirome: a review of its antibacterial activity, pharmacokinetic properties and clinical efficacy in the treatment of severe nosocomial infections and febrile neutropenia
- Development of an analytical method for cefpirome in plasma by simplified HPLC technique and its applications
- Stability-Indicating HPLC and RP-TLC Determination of Cefpirome Sulfate with Kinetic Study
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