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CAS RN: 427-51-0 | 产品编码: C2942
Cyproterone Acetate
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| 产品编码 | C2942 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__4H__2__9ClO__4 = 416.94 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 427-51-0 |
| Reaxys-RN | 2342172 |
| PubChem物质ID | 253660432 |
| Merck Index (14) | 2774 |
| MDL编号 | MFCD00864671 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 206.0 to 211.0 °C |
| Specific rotation [a]20/D | +148.0 to +156.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 209 °C |
| 比旋光度 [α]D | 152° (C=1,CHCl3) |
| 最大吸收波长 | 281 nm (MeOH) |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 52 mg/l 25 °C |
| 溶解性（可溶于） | 甲醇 |
| 溶解性（微溶于） | 乙醇 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H360 : May damage fertility or the unborn child. H351 : Suspected of causing cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | GZ2230000 |
运输信息
| HS编码* | 2937.29-000 |
应用
Cyproterone Acetate: A Synthetic Progestogen with Antiandrogenic Activity
Cyproterone acetate is a synthetic progestogen, which have antiandrogenic activity. It acts mainly by blocking androgen receptors, but also reduces the activity of skin 5α-reductase in sebaceous glands and hair follicles. It is primarily used in the treatment of androgen-related conditions such as acne, androgen dependent alopecia and prostate cancer. (The product is for research purpose only.)
References
- The antiandrogen cyproterone acetate: discovery, chemistry, basic pharmacology, clinical use and tool in basic research (a review)
- Antiandrogens: selective androgen receptor modulators (a review)
- Progestogens with antiandrogenic properties (a review)
- Antiandrogens in the treatment of prostate cancer (a review)
参考文献
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