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CAS RN: 154361-50-9 | 产品编码: C2878

Capecitabine


纯度/分析方法: >98.0%(T)(HPLC)
别名:
  • 卡培他滨
  • 5'-脱氧-5-氟-N4-[(戊氧基)羰基]胞啶
  • 5'-Deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine
产品文档:
1G
S$171.00
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5G
S$589.50
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产品编码 C2878
纯度/分析方法 >98.0%(T)(HPLC)
分子式/分子量 C__1__5H__2__2FN__3O__6 = 359.35 
外观与形状(20°C) 固体
储存温度 冷藏 (0-10°C)
应避免的情况 加热
包装和容器 1G-Glass Bottle with Plastic Insert (查看图片)
CAS RN 154361-50-9
Reaxys-RN 8583270
PubChem物质ID 253661933
Merck Index (14) 1754
MDL编号

MFCD00930626

技术规格
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Specific rotation [a]20/D +96.0 to +100.0 deg(C=1, MeOH)
物性(参考值)
熔点 123 °C(dec.)
比旋光度 [α]D 98° (C=1,MeOH)
水溶性 微溶
在水中的溶解度 26 g/l   20 °C
GHS
象形图 Pictogram Pictogram
信号词 Danger
危险性说明 H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H360 : May damage fertility or the unborn child.
防范说明 P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P405 : Store locked up.
相关法规
RTECS# HA3852500
运输信息
HS编码* 2934.99-000
*此H.S.编码用于日本出口报关,不适用于您所在国家或地区的进口申报
应用
Capecitabine: A Prodrug of 5-fluorouracil (5-FU) [F0151] for Selective Delivery to Tumor

Capecitabine is a prodrug of antitumor antimetabolite, metabolized to the active form 5-fluorouracil (5-FU) [F0151] by three enzymes located in the liver and in tumors. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine [D4342] and 5'-deoxy-5-fluorouridine (doxifluridine) [D3579], to form 5-FU. Capecitabine and its intermediary metabolites are not cytotoxic by themselves. The final step (doxifluridine to 5-FU) requires thymidine phosphorylase (dThdPase) that is significantly more active in tumor than normal tissue. This tumor-selective delivery of 5-FU ensured greater efficacy and a more favorable safety profile than with other fluoropyrimidines. For your reference, [D5787] is a synthetic precursor of capecitabine. (The product is for research purpose only.)

References


参考文献


TCIMail
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技术规格
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