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CAS RN: 434937-12-9 | 产品编码: C2421
1-(Cyanomethyl)piperidinium Tetrafluoroborate
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 103.0 to 107.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 105 °C |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H314 : Causes severe skin burns and eye damage. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P362 + P364 : Take off contaminated clothing and wash it before reuse. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P405 : Store locked up. |
相关法规
运输信息
| UN编号 | UN1759 |
| 类别 | 8 |
| 包装类别 | III |
| HS编码* | 2933.39-000 |
应用
A Useful Condensation Activator Bearing Less Nucleophilicity and No Deliquescence
Wada et al. developed 1-(cyanomethyl)piperidinium tetrafluoroborate (1) conjugates, with a highly less nucleophilic counteranion, BF4-.1) It has appropriate proton-donating ability as a condensation activator to give the corresponding dinucleotide without any loss of the diastereopurity. In addition, the activator has no deliquescence and good solubility in CH3CN. Therefore, the activator can be broadly applicable to condensation reactions.
References
- 1)Synthesis of oligonucleoside phosphorothioates via the condensation reactions using 1-(cyanomethyl)piperidinium tetrafluoroborate
- a)N. Oka, T. Wada, K. Saigo, J. Am. Chem. Soc. 2002, 124, 4962.
- b)N. Oka, T. Wada, K. Saigo, J. Am. Chem. Soc. 2003, 125, 8307.
- c)S. Fujiwara, N. Iwamoto, K. Saigo, T. Sato, T. Wada, PCT Int. Appl. WO 2005092909.
- a)N. Oka, T. Wada, K. Saigo, J. Am. Chem. Soc. 2002, 124, 4962.
PubMed Literature
文档
技术文章
[TCIMAIL No.150] A Useful Condensation Activator Bearing Less Nucleophilicity and No Deliquescence产品文档 (部分产品的分析图谱无法提供，敬请谅解。)
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