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CAS RN: 147-94-4 | 产品编码: C2035
Cytarabine
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | C2035 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__9H__1__3N__3O__5 = 243.22 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 147-94-4 |
| 相关CAS RN | 69-74-9 |
| Reaxys-RN | 89175 |
| PubChem物质ID | 87558791 |
| Merck Index (14) | 2784 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +155.0 to +162.0 deg(C=1, H2O) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 214 °C |
| 比旋光度 [α]D | 158° (C=1,H2O) |
| 最大吸收波长 | 272 nm (H__2O) |
| 水溶性 | 可溶 |
GHS
相关法规
| RTECS# | HA5425000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Cytarabine (ara-C): D-Arabinosyl Nucleoside exhibiting Anti-Leukemia and Anti-DNA Virus Activities
Certain D-arabinosyl nucleosides, notably cytarabine (ara-C) and vidarabine (ara-A) [V0098] are used as an anti-leukemia agent and an anti-DNA virus agent. Ara-C and ara-A are cell cycle phase-specific antineoplastic agents, affecting cells only during the S-phase of cell division. Intracellularly, ara-C and ara-A are converted into the 5-triphosphates (ara-CTP and ara-ATP), which are the active metabolites. The mechanism of actions are not completely understood, but it appear that ara-CTP and ara-ATP act through the inhibition of tumor cell or virus-induced DNA polymerases, competing with dCTP and dATP, respectively. Incorporation of them into DNA and RNA also contribute to their cytotoxicity. (The product is for research purpose only.)
References
- The mechanisms of lethal action of arabinosyl cytosine (araC) and arabinosyl adenine (araA) (a review)
- Ara-C: cellular and molecular pharmacology (a review)
- Acute Myeloid Leukemia (a review)
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