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CAS RN: 303-26-4 | 产品编码: C1611
1-(4-Chlorobenzhydryl)piperazine
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| 产品编码 | C1611 |
| 纯度/分析方法 | >98.0%(GC) |
| 分子式/分子量 | C__1__7H__1__9ClN__2 = 286.80 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 303-26-4 |
| Reaxys-RN | 243027 |
| PubChem物质ID | 87566606 |
| MDL编号 | MFCD00005965 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 72.0 to 76.0 °C |
物性（参考值）
| 熔点 | 75 °C |
| 沸点 | 180 °C/0.8 mmHg |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | TL1772000 |
运输信息
| HS编码* | 2933.59-000 |
应用
A Key Synthetic Intermediate of Cetirizine Dihydrochloride
This product has been used as a key synthetic intermediate of cetirizine dihydrochloride [C2316] which is a second-generation histamine H1-receptor antagonist.
References
- Synthesis of piperazine derivatives and evaluation of their antihistamine and antibradykinin effects
- Development and validation of a heart-cutting liquid chromatography-mass spectrometry method for the determination of process-related substances in cetirizine tablets
- Determination of levocetirizine configurational stability in tablets using chiral HPLC method
参考文献
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技术规格
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