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CAS RN: 76513-69-4 | 产品编码: C1339
2-(Chloromethoxy)ethyltrimethylsilane (stabilized with Diisopropylethylamine)
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纯度/分析方法: >95.0%(GC)
别名：
- 2-(氯甲氧基)乙基三甲硅烷 (含稳定剂二异丙基乙胺)
- SEM-氯化物 (含稳定剂二异丙基乙胺)
- 2-(三甲基硅基)乙氧基甲基氯 (含稳定剂二异丙基乙胺)
- SEM-Chloride (stabilized with Diisopropylethylamine)
- 2-(Trimethylsilyl)ethoxymethyl Chloride (stabilized with Diisopropylethylamine)
产品文档：
技术规格
| Appearance | Colorless to Almost colorless clear liquid |
| Purity(GC) | min. 95.0 % |
物性（参考值）
| 沸点 | 59 °C/8 mmHg |
| 闪点 | 46 °C |
| 比重 | 0.95 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H314 : Causes severe skin burns and eye damage. H226 : Flammable liquid and vapor. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P240 : Ground/bond container and receiving equipment. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P233 : Keep container tightly closed. P243 : Take precautionary measures against static discharge. P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment. P242 : Use only non-sparking tools. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P403 + P235 : Store in a well-ventilated place. Keep cool. P405 : Store locked up. |
相关法规
运输信息
| UN编号 | UN2920 |
| 类别 | 8 / 3 |
| 包装类别 | II |
| HS编码* | 2931.90-000 |
应用
TCI Practical Example: SEM-Protection by Using 2-(Chloromethoxy)ethyltrimethylsilane
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Used Chemicals
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Procedure
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Sodium hydride (49.0 mg, 1.22 mmol) in DMF (1 mL) was stirred at 0 °C for 5 minutes and 5-bromoindole (200 mg, 1.02 mmol) was added to the solution and stirred at 0 °C for 10 minutes. Then SEM-Cl (220 µL, 1.28 mmol) in DMF (0.5 mL) was added to the solution and stirred at 0 °C for 20 minutes. The reaction was quenched with water and the aqueous layer was extracted with ethyl acetate and washed with brine. The organic phase was dried over anhydrous sodium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate:hexane = 0:100 - 5:95) to give 1 as a colorless oil (256 mg, 77% yield).
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Experimenter’s Comments
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The reaction mixture was monitored by TLC (ethyl acetate:hexane = 1:9, Rf = 0.47).
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Analytical Data
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5-Bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indole (1)
1H NMR (270 MHz, CDCl3); δ 7.75 (d, J = 1.6 Hz, 1H), 7.38–7.32 (m, 2H), 7.16 (d, J = 3.2 Hz, 1H), 6.46 (d, J = 3.2 Hz, 1H), 5.45 (s, 2H), 3.47–3.41 (m, 2H), 0.90–0.84 (m, 2H), -0.07 (s, 9H).
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Lead Reference
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- Protecting groups for the pyrrole and indole nitrogen atom. The [2-(trimethylsilyl)ethoxy]methyl moiety. Lithiation of 1-[[2-(trimethylsilyl)ethoxy]methyl]pyrrole
参考文献