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CAS RN: 124-87-8 | 产品编码: C0375
Picrotoxin (Picrotoxinin + Picrotin)
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| 产品编码 | C0375 |
| 纯度/分析方法 | >94.0%(HPLC) |
| 分子式/分子量 | C__3__0H__3__4O__1__3 = 602.59 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 124-87-8 |
| PubChem物质ID | 87565507 |
| SDBS (AIST Spectral DB) | 10888 |
| Merck Index (14) | 7415 |
| MDL编号 | MFCD00074824 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 94.0 %(Picrotoxinin and Picrotin mixture) |
物性（参考值）
| 熔点 | 200 °C |
| 溶解性（可溶于） | 乙醇 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H300 : Fatal if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | TJ9100000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | II |
| HS编码* | 2939.79-000 |
应用
Picrotoxin: A Natural Sesquiterpene Antagonist of GABAA Receptors
Picrotoxin is a sesquiterpene that occurs naturally in the fruit of the Anamirta cocculus which a wild woody climber, distributed throughout India as well as South-East Asia. Picrotoxin is a mixture of two compounds, picrotoxinin and picrotin. Of the two compounds, picrotoxinin is the active ingredient. Picrotoxinin is a naturally occurring poison that a noncompetitive antagonist of GABAA receptors (GABARs), the primary mediators of inhibitory neurotransmission in the nervous system. Picrotoxinin prevents ion flow through the chloride channel activated by GABA in the GABAR, a member of the cys-loop, ligand-gated ion channel superfamily. (The product is for research purpose only.)
References
- Picrotoxin-like channel blockers of GABA receptors (a review)
参考文献
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