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CAS RN: 120410-24-4 | 产品编码: B5522
Biapenem
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| 产品编码 | B5522 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__5H__1__8N__4O__4S = 350.39 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| CAS RN | 120410-24-4 |
| Reaxys-RN | 7394875 |
| Merck Index (14) | 1197 |
| MDL编号 | MFCD00864863 |
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 15.20 to 16.70 % |
| Specific rotation [a]20/D | -30.0 to 335.0 deg(C=0.5, H2O) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 226 °C(dec.) |
| 比旋光度 [α]D | -33° (C=0.5,H2O) |
| 水溶性 | 微溶 |
| 溶解性（不溶于） | 甲醇, 乙醇, 乙醚 |
GHS
相关法规
运输信息
| HS编码* | 2941.90-000 |
应用
Biapenem: A Carbapenem Antibacterial Agent against Pseudomonas aeruginosa
Biapenem (LJC 10627) is a carbapenem antibacterial agent that has antibacterial and fungicidal activity against a wide range of Gram-positive and -negative bacteria, including species producing β-lactamases. Biapenem also has activity against Pseudomonas aeruginosa which isolates with broad-spectrum insusceptibility to penicillins and cephalosporins. Biapenem inhibits murein biosynthesis which is needed by bacteria to make their cell walls. In addition, biapenem is more stable than meropenem [M2279] to metabolic hydrolysis by human renal dihydropeptidase-I (DHP-I). (The product is for research purpose only.)
References
- In vitro activity of LJC10,627, a new carbapenem antibiotic with high stability to dehydropeptidase I
- Renal dehydropeptidase-I stability of LJC 10,627, a new carbapenem antibiotic
- In-vitro activity of biapenem, compared with imipenem and meropenem, against Pseudomonas aeruginosa strains and mutants with known resistance mechanisms
- Biochemical comparison of imipenem, meropenem and biapenem: permeability, binding to penicillin-binding proteins, and stability to hydrolysis by β-lactamases
- Biapenem (a review)
- The stability of biapenem and structural identification of impurities in aqueous solution
- A simple and rapid determination of biapenem in plasma by high-performance liquid chromatography
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