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CAS RN: 714971-09-2 | 产品编码: B5520
BMS-599626
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纯度/分析方法: >98.0%(HPLC)
别名：
- BMS-599626
- [4-[[1-(3-氟苄基)-1H-吲唑-5-基]氨基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氨基甲酸(S)-吗啉-3-基甲酯
- AC 480
- (S)-Morpholin-3-ylmethyl [4-[[1-(3-Fluorobenzyl)-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate
产品文档：
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 20.00 to 22.00 % |
| NMR | confirm to structure |
物性（参考值）
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
BMS-599626: A Highly Selective Inhibitor of HER1 and HER2
BMS-599626 (or AC480) is a highly selective inhibitor of human epidermal growth factor receptors (HER) kinase family which plays essential roles in regulating cell proliferation, survival, differentiation and migration. BMS-599626 modulates signaling and growth of tumor cells that depend on HER1 and/or HER2. Reportedly, BMS-599626 inhibits HER1 and HER2 with IC50 of 20 and 30 nmol/L, respectively. (The product is for research purpose only.)
References
- Preclinical Antitumor Activity of BMS-599626, a pan-HER Kinase Inhibitor That Inhibits HER1/HER2 Homodimer and Heterodimer Signaling
- HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924
- AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo
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