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CAS RN: 42864-78-8 | 产品编码: B5372
Bevantolol Hydrochloride
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纯度/分析方法: >98.0%(HPLC)
别名：
- 盐酸贝凡洛尔
- 1-[[2-(3,4-二甲氧基苯基)乙基]氨基]-3-(3-甲基苯氧基)-2-丙醇盐酸盐
- 1-[(3,4-二甲氧基苯乙基)氨基]-3-(间甲苯氧基)丙-2-醇盐酸盐
- 1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol Hydrochloride
- 1-[(3,4-Dimethoxyphenethyl)amino]-3-(m-tolyloxy)propan-2-ol Hydrochloride
产品文档：
| 产品编码 | B5372 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__0H__2__7NO__4·HCl = 381.90 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 42864-78-8 |
| 相关CAS RN | 59170-23-9 |
| Reaxys-RN | 5195067 |
| PubChem物质ID | 354334983 |
| Merck Index (14) | 1192 |
| MDL编号 | MFCD00941389 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 139.0 to 144.0 °C |
物性（参考值）
| 熔点 | 142 °C |
| 溶解性（可溶于） | 氯仿 |
| 溶解性（不溶于） | 乙醚 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
运输信息
| HS编码* | 2922.50-000 |
应用
Bevantolol Hydrochloride: A β1-Adrenoceptor Antagonist with an Affinity to α1-Adrenoceptors
Bevantolol hydrochloride (NC-1400) is a β1-adrenoceptor antagonist with a relatively high affinity to α1-adrenoceptor subtypes, and also acts as calcium channel antagonist. Bevantolol has a peripheral vasodilatory effect, and is used for the treatment of angina and hypertension. In addition, bevantolol hydrochloride is a racemic mixture, and methods have been developed for the enantioselective separation. (The product is for research purpose only.)
References
- (±)-1-[[2-(3,4-Dimethoxphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol hydrochloride (bevantolol, NC-1400) as a β1-selective adrenoceptor blocker with α1-adrenoceptor blocking activity
- Alpha1-adrenoceptor blocking activities of bevantolol hydrochloride(NC-1400) and labetalol in rat isolated thoracic aorta - Do they distinguish between subtypes?
- Bevantolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and angina pectoris
- Quantitative analysis of β-adrenergic blocking agents by NMR spectroscopy
- Chiral purity test of bevantolol by capillary electrophoresis and high performance liquid chromatography
- Determination of bevantolol enantiomers in human plasma by coupled achiral-chiral high performance-liquid chromatography
参考文献
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