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CAS RN: 157212-55-0 | 产品编码: B5118
Bosentan Monohydrate
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纯度/分析方法: >98.0%(HPLC)
别名：
- 波生坦 一水合物
- 4-(叔丁基)-N-[6-(2-羟乙氧基)-5-(2-甲氧基苯氧基)[2,2'-联嘧啶]-4-基]苯磺酰胺 一水合物
- 4-叔丁基-N-[6-(2-羟乙氧基)-5-(2-甲氧基苯氧基)-2-(嘧啶-2-基)嘧啶-4-基]苯磺酰胺 一水合物
- 4-(tert-Butyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide Monohydrate
- 4-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzenesulfonamide Monohydrate
产品文档：
| 产品编码 | B5118 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__7H__2__9N__5O__6S·H__2O = 569.64 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 157212-55-0 |
| 相关CAS RN | 147536-97-8 |
| Reaxys-RN | 9031515 |
| PubChem物质ID | 354334055 |
| Merck Index (14) | 1353 |
| MDL编号 | MFCD09751188 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 11.60 to 12.90 % |
| Water | 2.5 to 4.0 % |
物性（参考值）
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 乙醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2935.90-000 |
应用
Bosentan: A Dual Endothelin Receptor Antagonist with Affinity for Both ETA and ETB Receptors
Endothelin-1 (ET-1) is a peptide that constricts pulmonary blood vessels and raise blood pressure. Two ET-1 receptor subtypes, ETA and ETB, mediate the effects of ET-1 in the vascular smooth muscle and endothelium. The actions of ETA would be vasoconstriction and cell proliferation, while the actions of ETB would be vasodilatation, antiproliferation, and ET-1 clearance. Bosentan is a dual endothelin receptor antagonist (ERA) with affinity for both endothelin A and B (ETA and ETB) receptors. At one time, the anti-fibrotic potential of bosentan was interested. For your reference, ambrisentan [A2966] is a selective ETA receptor antagonist. (The product is for research purpose only.)
References
- Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist
- Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan)
- Endothelin-1 is involved in norepinephrine-induced ventricular hypertrophy in vivo: Acute effects of bosentan, an orally active, mixed endothelin ETA and ETB receptor antagonist
- Clinical pharmacology of bosentan, a dual endothelin receptor antagonist (a review)
- Role of endothelin in fibrosis and anti-fibrotic potential of bosentan (a review)
参考文献
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