Benfotiamine

Reference

• Paraptosis Cell Death Induction by the Thiamine Analog Benfotiamine in Leukemia Cells
  • N. Sugimori, J.L. Espinoza, L.Q. Trung, A. Takami, Y. Kondo, D.T. An, M. Sasaki, T. Wakayama, S. Nakao, PLoS ONE 2015, 10, e0120709.


应用
Benfotiamine: S-Acyl Derivative of Thiamine with High Bioavailability
S-benzoylthiamine O-monophoshate (benfotiamine) is a synthetic S-acyl derivative of thiamine (vitamin B₁). Benfotiamine is absorbed in vivo much more than water soluble thiamine hydrochloride [T0181]. Benfotiamine increases the levels of intracellular thiamine diphosphate, a cofactor necessary for the activation transketolase, resulting in the reduction of tissue level of advanced glycation end products (AGEs) which can be a factor in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic renal failure and Alzheimer's disease.

References

• Pharmacokinetics of thiamine derivatives, especially of benfotiamine (a review)
  • D. Loew, Int. J. Clin. Pharmacol. Ther. 1996, 34, 47.
• Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats
  • H. Stracke, H. P. Hammes, D. Werkmann, K. Mavrakis, I. Bitsch, M. Netzel, J. Geyer, W. Köpcke, C. Sauerland, R. G. Bretzel, K. F. Federlin, Exp. Clin. Endocrinol. Diabetes 2001, 109, 330.
• Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
  • H.-P. Hammes, X. Du, D. Edelstein, T. Taguchi, T. Matsumura, Q. Ju, J. Lin, A. Bierhaus, P. Nawroth, D. Hannak, M. Neumaier, R. Bergfeld, I. Giardino, M. Brownlee, Nat. Med. 2003, 9, 294.
• Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes
  • A. Stirban, M. Negrean, B. Stratmann, T. Gawlowski, T. Horstmann, C. Götting, K. Kleesiek, M. Mueller-Roesel, T. Koschinsky, J. Uribarri, H. Vlassara, D. Tschoepe, Diabetes Care 2006, 29, 2064.
• The multifaceted therapeutic potential of benfotiamine (a review)
  • P. Balakumar, A. Rohilla, P. Krishan, P. Solairaj, A. Thangathirupathi, Pharmacol. Res. 2010, 61, 482.


参考文献