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CAS RN: 132810-10-7 | 产品编码: B4565
Blonanserin
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| 产品编码 | B4565 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__2__3H__3__0FN__3 = 367.51 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 132810-10-7 |
| Reaxys-RN | 9957203 |
| PubChem物质ID | 253660431 |
| Merck Index (14) | 1319 |
| MDL编号 | MFCD00893838 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 10.80 to 12.00 % |
| Melting point | 123.0 to 127.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 124 °C |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | GY0175140 |
运输信息
| HS编码* | 2933.99-000 |
应用
Blonanserin: An Antagonist at Dopamine D2 and Serotonin 5-HT2A Receptors
Blonanserin (AD-5423) is an atypical antipsychotic agent having the properties of both a serotonin 5-HT2A and a dopamine D2 receptor antagonist. Blonanserin differs from mainly used serotonin 5-HT2A/dopamine-D2 receptor antagonists (eg: risperidone [R0087] and olanzapine [O0393]) in that it exhibits higher affinity for dopamine-D2 receptors than for serotonin 5-HT2A receptors. (The product is for research purpose only.)
References
- 1)Pharmacological profile of AD-5423, a novel antipsychotic with both potent dopamine-D2 and serotonin-S2 antagonist properties
- 2)Effect of novel atypical antipsychotic, blonanserin, on extracellular neurotransmitter level in rat prefrontal cortex
- 3)Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism
- 4)Simple analysis of blonanserin, a novel antipsychotic agent, in human plasma by GC-MS
- 5)Profile of blonanserin for the treatment of schizophrenia (a review)
PubMed Literature
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