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CAS RN: 51333-22-3 | 产品编码: B3909
Budesonide
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| 产品编码 | B3909 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__5H__3__4O__6 = 430.54 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 51333-22-3 |
| Reaxys-RN | 3633996 |
| PubChem物质ID | 160871371 |
| Merck Index (14) | 1468 |
| MDL编号 | MFCD00083259 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 % (total of isomers) |
| Elemental analysis(Carbon) | 68.00 to 71.00 % |
| Specific rotation [a]20/D | +100 to +110 deg(C=0.28、CH2Cl2) |
物性（参考值）
| 比旋光度 [α]D | 105° (C=0.28,CH2Cl2) |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 氯仿, 甲醇 |
| 溶解性（微溶于） | 丙酮, 乙醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | TU3723000 |
运输信息
| HS编码* | 2937.29-000 |
应用
Budesonide: A Potent Glucocorticoid Receptor Antagonist
Budesonide is an anti-inflammatory corticosteroid that exhibits potent glucocorticoid activity and weak mineralocorticoid activity.1-6） Budesonide has a strong affinity for glucocorticoid receptor, and it is reported that budesonide has approximately 8.5-fold, 15-fold, and 195-fold greater than those of dexamethasone [D1961], prednisolone [P0637], and hydrocortisone [H0533], respectively.6) Budesonide is mainly metabolized by CYP3A4.6) (The product is for research purpose only.)
References
- 1)Scientific rationale for inhaled combination therapy with long-acting β2-agonists and corticosteroids(a review)
- 2)Budesonide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in asthma and rhinitis(a review)
- 3)Budesonide: A review of its pharmacological properties and therapeutic efficacy in inflammatory bowel disease(a review)
- 4)Topical delivery of therapeutic agents in the treatment of inflammatory bowel disease(a review)
- 5)Treatment of inflammatory bowel disease: a review of medical therapy(a review)
- 6)Budesonide Multi-matrix for the Treatment of Patients with Ulcerative Colitis (a review)
参考文献
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