Bis(phenylacetyl) Disulfide

文献

• Nucleic acid therapeutics: basic concepts and recent developments
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• 3H-1,2-Benzodithiol-3-one 1,1-dioxide
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• Phosphorothioate Oligonucleotides with Low Phosphate Diester Content:  Greater than 99.9% Sulfurization Efficiency with “Aged” Solutions of Phenylacetyl Disulfide (PADS)
  • A. H. Krotz, D. Gorman, P. Mataruse, C. Foster, J. D. Godbout, C. C. Coffin, A. N. Scozzari, Org. Proc. Res. Dev. 2004, 8, 852.
• Large-Scale Synthesis of Oligonucleotide Phosphorothioates Using 3-Amino-1,2,4-dithiazole-5-thione as an Efficient Sulfur-Transfer Reagent
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• Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride)
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References

• An efficient approach toward the synthesis of phosphorothioate diesters via the schönberg reaction
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• Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent)
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• Use of phenylacetyl disulfide (PADS) in the synthesis of oligodeoxyribonucleotide phosphorothioates
  • Z. S. Cheruvallath, P. D. Wheeler, D. L. Cole, V. T. Ravikumar, Nucleosides Nucleotides 1999, 18, 485.
• Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides: Adduct
  • D. C. Capaldi, H. Gaus, A. H. Krotz, J. Arnold, R. L. Carty, M. N. Moore, A. N. Scozzari, K. Lowery, D. L. Cole, V. T. Ravikumar, Org. Process Res. Dev. 2003, 7, 832.
• Phosphorothioate Oligonucleotides with Low Phosphate Diester Content: Greater than 99.9% Sulfurization Efficiency
  • A. H. Krotz, D. Gorman, P. Mataruse, C. Foster, J. D. Godbout, C. C. Coffin, A. N. Scozzari, Org. Process Res. Dev. 2004, 8, 852.