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CAS RN: 100-39-0 | 产品编码: B0411
Benzyl Bromide (stabilized with Propylene Oxide)
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 25G |
S$33.00
|
≥40 | ≥100 |
|
| 100G |
S$84.00
|
≥40 | ≥40 |
|
| 500G |
S$277.50
|
≥80 | ≥40 |
|
技术规格
| Appearance | Colorless to Light yellow to Light orange clear liquid |
| Purity(GC) | min. 98.0 % |
物性（参考值）
| 沸点 | 199 °C |
| 闪点 | 79 °C |
| 比重 | 1.44 |
| 折射率 | 1.58 |
| 溶解性（可与之混溶） | 乙醚 |
| 溶解性（可溶于） | 苯 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H330 : Fatal if inhaled. H314 : Causes severe skin burns and eye damage. H341 : Suspected of causing genetic defects. H335 : May cause respiratory irritation. H227 : Combustible liquid. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P202 : Do not handle until all safety precautions have been read and understood. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P403 + P235 : Store in a well-ventilated place. Keep cool. P405 : Store locked up. |
相关法规
| RTECS# | XS7965000 |
运输信息
| UN编号 | UN1737 |
| 类别 | 6.1 / 8 |
| 包装类别 | II |
| HS编码* | 2903.99-000 |
应用
TCI Practical Example: Protection of Hydroxy with Benzyl Ether Using Benzyl Bromide
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Used Chemicals
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Procedure
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4-bromophenethyl alcohol (500 mg, 2.49 mmol) in dry THF (4.0 mL) were added to a suspension of NaH (60%, 219 mg, 5.47 mmol, 2.2 eq.) in dry THF (4.0 mL) at 0 °C. Benzyl bromide (354 µL, 2.98 mmol, 1.2 eq.) was added to the mixture and stirred at room temperature for 1 day. The reaction mixture was quenched with H2O (10 mL) dropwise at 0 °C and the aqueous layer was extract with ethyl acetate (2 x 10 mL), and washed with brine. Organic layer was dried over sodium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by column chromatography (dichloromethane:hexane = 0:100 – 15:85 – 25:75 on silica gel), giving 1 a pale yellow liquid (536.7 mg, 74% yield.).
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Experimenter’s Comments
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The reaction mixture was monitored by TLC (ethyl acetate:hexane = 1:10, Rf = 0.55).
Because BnBr has lachrymatory property, this experiment was carried out in the draft chamber.
Since NaH reacts with water to generate hydrogen, which may ignite or explode, water was carefully added dropwise when the reaction was quenched.
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Analytical Data
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Compound 1
1H NMR (400 MHz, CDCl3); δ 7.43-7.25 (m, 7H), 7.11 (m, 2 H), 4.51 (s, 2H), 3.66 (t, J = 7.0 Hz, 2H), 2.87 (t, J = 7.0 Hz, 2H).
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Other Reference
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- Enhancing polo-like kinase 1 selectivity of polo-box domain-binding peptides
参考文献