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CAS RN: 497839-62-0 | 产品编码: A3271
AEE 788
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纯度/分析方法: >98.0%(HPLC)
别名：
- AEE 788
- (R)-6-[4-[(4-乙基哌嗪-1-基)甲基]苯基]-N-(1-苯乙基)-7H-吡咯并[2,3-d]嘧啶-4-胺
- 6-[4-[(4-乙基-1-哌嗪基)甲基]苯基]-N-[(1R)-1-苯乙基]-7H-吡咯并[2,3-d]嘧啶-4-胺
- (R)-6-[4-[(4-Ethylpiperazin-1-yl)methyl]phenyl]-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
产品文档：
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 245.0 to 249.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 247 °C |
GHS
相关法规
| RTECS# | UY8836200 |
运输信息
| HS编码* | 2933.59-000 |
应用
AEE788: A Dual Inhibitor of EGFR and VEGFR Tyrosine Kinase Family Members
AEE788 is an orally available and potent dual family of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) tyrosine kinases inhibitor. It has been reported that AEE788 exhibits potent antitumor and antiangiogenic activity. (The product is for research purpose only.)
References
- AEE788: A Dual Family Epidermal Growth Factor Receptor/ErbB2 and Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor with Antitumor and Antiangiogenic Activity
- Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model
- Combined inhibition of the VEGFR and EGFR signaling pathways in the treatment of NSCLC (a review)
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技术规格
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