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CAS RN: 170729-80-3 | 产品编码: A3135
Aprepitant
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纯度/分析方法: >98.0%(HPLC)
别名：
- 阿瑞吡坦
- 5-[[(2R,3S)-2-[(1R)-1-[3,5-二(三氟甲基)苯基]乙氧基]-3-(4-氟苯基)-4-吗啉基]甲基]-1,2-二氢-3H-1,2,4-三唑-3-酮
- 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
产品文档：
| 产品编码 | A3135 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__3H__2__1F__7N__4O__3 = 534.43 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 500MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 170729-80-3 |
| Reaxys-RN | 8096869 |
| PubChem物质ID | 354334991 |
| Merck Index (14) | 753 |
| MDL编号 | MFCD08277635 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 249.0 to 253.0 °C |
| Specific rotation [a]20/D | +67.0 to +71.0 deg(C=1,MeOH) |
物性（参考值）
| 熔点 | 252 °C |
| 比旋光度 [α]D | 69° (C=1,MeOH) |
| 水溶性 | 不溶 |
| 溶解性（微溶于） | 乙醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H319 : Causes serious eye irritation. H351 : Suspected of causing cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P405 : Store locked up. |
相关法规
| RTECS# | XZ5480400 |
运输信息
| HS编码* | 2934.99-000 |
应用
Aprepitant: A Selective High-Affinity Antagonist of the Substance P/Neurokinin 1 (NK1) Receptors
Aprepitant is a selective high-affinity antagonist of the substance P/neurokinin 1 (NK1) receptors. Aprepitan crosses the blood barrier, and then aprepitan occupies brain NK1 receptors and blocks the binding of substance P to the receptors. (Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.) Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors. Aprepitant is used for the treatment of nausea and vomiting. (The product is for research purpose only.)
References
- Aprepitant - a novel NK1-receptor antagonist (a review)
- Aprepitant: A review of its use in the prevention of chemotherapy-induced nausea and vomiting
- Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting (a review)
- Simultaneous determination of Aprepitant and two metabolites in human plasma by high-performance liquid chromatography with tandem mass spectrometric detection
- A sensitive and rapid liquid chromatography-tandem mass spectrometry method for the quantification of the novel neurokinin-1 receptor antagonist aprepitant in rhesus macaque plasma, and cerebral spinal fluid, and human plasma with application in translational NeuroAIDs research
- A validated stability indicating RP-HPLC method for the determination of aprepitant in bulk and pharmaceutical dosage forms
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