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CAS RN: 141396-28-3 | 产品编码: A2705
Argatroban Monohydrate
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 25MG |
S$355.50
|
2 | 36 |
|
| 产品编码 | A2705 |
| 纯度/分析方法 | >99.0%(HPLC) |
| 分子式/分子量 | C__2__3H__3__6N__6O__5S·H__2O = 526.66 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 光,加热 |
| CAS RN | 141396-28-3 |
| 相关CAS RN | 74863-84-6 |
| PubChem物质ID | 253661816 |
| Merck Index (14) | 779 |
| MDL编号 | MFCD00895735 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Elemental analysis(Nitrogen) | 15.50 to 16.50 % |
| Specific rotation [a]20/D | +160.0 to +170.0 deg(C=0.8, MeOH)(calcd.on anh.substance) |
| Water | 2.5 to 4.5 % |
物性（参考值）
| 熔点 | 180 °C(dec.) |
| 比旋光度 [α]D | 165° (C=0.8,MeOH) |
| 水溶性 | 不溶 |
| 溶解性（微溶于） | 甲醇 |
| 溶解性（不溶于） | 乙醚, 丙酮 |
GHS
相关法规
| RTECS# | TM6126625 |
运输信息
| HS编码* | 2935.90-000 |
应用
Argatroban: A Direct Thrombin Inhibitor Act as an Anticoagulant
Argatroban is a synthetic selective thrombin inhibitor. It is known that argatroban exerts inhibiting activities on fibrin generation, platelet aggregation and vasoconstriction by direct interacting with thrombin. Due to these activities, argatoroban is utilized as an ingredient for anticoagulant and antithrombotic. Argatroban is also used as one of positive control drugs for thrombosis model animals. (This product is for research purpose only.)
References
- Comparative study on heparin and a synthetic thrombin inhibitor no. 805 (MD-805*) in experimental antithrombin III-deficient animals
- Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its hydrophobic carboxamide portion
- Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl]-2-piperidinecarboxylic acid
- Antithrombotic actions of argatroban in rat models of venous, 'mixed' and arterial thrombosis, and its effects on the tail transection bleeding time
- Effects of a thrombin inhibitor, argatroban, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.
- Argatroban (a review)
- Direct thrombin inhibitors in acute coronary syndromes: present and future (a review)
- Argatroban: Update (a review)
参考文献
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