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CAS RN: 136470-78-5 | 产品编码: A2694
Abacavir
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | A2694 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__4H__1__8N__6O = 286.34 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 136470-78-5 |
| Reaxys-RN | 7493116 |
| PubChem物质ID | 253661597 |
| Merck Index (14) | 1 |
| MDL编号 | MFCD00903850 |
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -53.0 to -57.0 deg(C=0.15, MeOH) |
物性（参考值）
| 熔点 | 161 °C(dec.) |
| 比旋光度 [α]D | -54° (C=0.15,MeOH) |
| 水溶性 | 不溶 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. H341 : Suspected of causing genetic defects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | GY5979200 |
运输信息
| HS编码* | 2933.59-000 |
应用
Abacavir: A Nucleoside Analog Reverse Transcriptase Inhibitor (RTI)
Abacavir is a nucleoside analog reverse transcriptase inhibitor (RTI) that inhibits HIV-1 in vitro with a potency similar to that of zidovudine [A2052]. Resistance to abacavir develops relatively slowly. Cross-resistance between abacavir and other RTIs, namely didanosine [D3066], zalcitabine [D3581] or lamivudine [L0217], but not zidovudine or stavudine [D3580], has been reported in vitro. HLA-B*5701 genetic screening have been reported to prevent drug hypersensitivity reactions caused by abacavir.
References
- Abacavir (a review)
- The antiviral activity, mechanism of action, clinical significance and resistance of abacavir in the treatment of pediatric AIDS (a review)
- HLA-B*5701 screening prior to abacavir prescription: Clinical and laboratory aspects (a review)
- Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV (a review)
参考文献
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