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CAS RN: 111470-99-6 | 产品编码: A2353
Amlodipine Besylate
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纯度/分析方法: >98.0%(HPLC)(qNMR)
别名：
- 苯磺酸氨氯地平
- 2-(2-氨基乙氧基)甲基-4-(2-氯苯基)-6-甲基-1,4-二氢吡啶-3,5-二甲酸3-乙基5-甲酯苯磺酸盐
- 3-Ethyl 5-Methyl 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Benzenesulfonate
- 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfonate
产品文档：
| 产品编码 | A2353 |
纯度/分析方法 
|
>98.0%(HPLC)(qNMR) |
| 分子式/分子量 | C__2__0H__2__5ClN__2O__5·C__6H__5SO__3H = 567.05 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 111470-99-6 |
| 相关CAS RN
|
88150-42-9 |
| Reaxys-RN | 8378713 |
| PubChem物质ID | 125307717 |
| SDBS (AIST Spectral DB) | 52867 |
| Merck Index (14) | 491 |
| MDL编号 | MFCD00887594 |
技术规格
| Appearance | White to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 200 °C(dec.) |
| 水溶性 | 微溶 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | US7967700 |
运输信息
| HS编码* | 2933.39-000 |
应用
Amlodipine Besylate: A Long-Acting Dihydropyridine-Type Calcium Channel Antagonist
Amlodipine besylate is a long-acting dihydropyridine-type calcium channel antagonist or blocker (CCB) that causes vasodilatation by blocking the influx of calcium ions through L-type calcium channels in cell membranes. Amlodipine besylate is slightly soluble in water, sparingly soluble in ethanol and soluble in methanol. Recently, some combination agents with an angiotensin II antagonist (ARB), such as irbesartan [I0859] and valsartan [V0112], are used for the treatment of hypertension and cardiovascular disease. For your reference, [P2406] is an impure substance in the synthesis of amlodipine besylate. (The product is for research purpose only.)
References
- Comparison of location and binding for the positively charged 1,4-dihydropyridine calcium channel antagonist amlodipine with uncharged drugs of this class in cardiac membranes.
- Amlodipine. A review of its pharmacodynamic and pharmaockinetic properties, and therapeutic use in cardiovascular disease
- Amlodipine: A reappraisal of its Pharmacological Properties and Therapeutic Use in Cardiovascular Disease
- Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells
- Novel vascular biology of 3rd-generation L-type calcium channel antagonists
- A stability-indicating high performance liquid chromatographic (HPLC) assay for the simultaneous determination of atorvastatin and amlodipine in commercial tablets
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