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CAS RN: 148893-10-1 | 产品编码: A1797
HATU
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技术规格
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
物性（参考值）
| 熔点 | 186 °C(dec.) |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P272 : Contaminated work clothing should not be allowed out of the workplace. P280 : Wear protective gloves. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
A Condensing Reagent
Experimental procedure1): L-leucine tert-butyl ester hydrochloride (1, 67 mg, 0.3 mmol), N-Fmoc-L-proline (2, 101 mg, 0.3 mmol) and HATU (171 mg, 0.45 mmol) are added to a flask under argon. Anhydrous dichloromethane (1 mL), anhydrous DMF (0.5 mL), and collidine (79 µL, 0.6 mmol) are added and stirred at room temperature for 3 hr. HCl (1 mol/L, 1 mL) is added and the reaction mixture is diluted with dichloromethane (3 mL) and washed with H2O (3 x 1.5 mL). The crude mixture is concentrated in vacuo and then purified by flash chromatography (hexane:EtOAc = 1:0 ~ 1:1) to yield 3 as a white solid (151 mg, 0.3 mmol) in 99% yield.
References
- 1)Progress toward the Total Synthesis of Lucentamycin A: Total Synthesis and Biological Evaluation of 8-epi-Lucentamycin A
- 2)The Uronium/Guanidinium Peptide Coupling Reagents: Finally the True Uronium Salts
参考文献
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技术文章
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相关产品
Reagents for Condensation Reactions (HATU) (HPMC encapsulated)
| 产品 | R0295 |
| CAS RN | 148893-10-1 |
| 纯度/分析方法 |