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CAS RN: 89-57-6 | 产品编码: A0317
5-Aminosalicylic Acid
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技术规格
| Appearance | White to Gray to Brown powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Solubility in HCl | almost transparency |
物性（参考值）
| 熔点 | 265 °C(dec.) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | VO1400000 |
运输信息
| HS编码* | 2922.50-000 |
应用
5-Aminosalicylic Acid (5-ASA): A Gastrointestinal Anti-Inflammatory Agent
5-Aminosalicylic acid (5-ASA or mesalazine) is used as a gastrointestinal anti-inflammatory agent. Although the mechanism of action remains unknown exactly, 5-ASA has in vitro and in vivo pharmacologic effects that decrease leukotriene production, scavenge for free radicals and inhibit leukocyte chemotaxis et al. For clinical purposes, amylose, ethyl cellulose or pH-dependent polymers coated 5-ASA are developed and used for drug delivery to the intestinal tract. In addition, sulfasalazine [S0580] is a prodrug of 5-ASA. (The product is for research purpose only.)
References
- Salicylates for ulcerative colitis - their mode of action (a review)
- Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers
- 5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells
- Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-γ
- Cyclooxygenase-2-dependent and -independent inhibition of proliferation of colon cancer cells by 5-aminosalicylic acid
- High-performance liquid-chromatographic determination of 5-aminosalicylic acid and its metabolites in blood plasma
参考文献
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![5-Aminosalicylic Acid [for Biochemical Research]](/medias/A2291.jpg?context=bWFzdGVyfHJvb3R8MzU5NTl8aW1hZ2UvanBlZ3xhRGRsTDJobE5TODRPVEk0TXpZM01ERTRNREUwTDBFeU1qa3hMbXB3Wnd8ZGM2YzMwMzE2MTFjYzUxZjE4NzhlNThlNzk3YjI2MzllNmI5MmQxMDU0YmRkMTBjZDAzODg4NTU0ODM5MmU4Nw "5-Aminosalicylic Acid [for Biochemical Research]")