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Synthetic Auxin with 1000-fold Stronger Binding Affinity than the Natural Auxin
No.187(August 2021)
A technique to induce degradation of target protein which has AID tag for binding to auxin, because auxin receptor protein (TIR1) acts as a F-box protein constituting SCF complex in ubiquitin-proteasome system is called Auxin-inducible degron (AID) system (Figure 1).1) 5-Adamantyl-IAA (1) has 1000-fold stronger affinity with modified TIR receptor protein than natural auxin.2) These make it possible to induce protein degradation in 1/1000 concentration auxin of original AID system, and a low toxic protein degradation has been reported in mouse and human cells.3)
References
- 1) An auxin-based degron system for the rapid depletion of proteins in nonplant cells
- 2) A Super Strong Engineered Auxin–TIR1 Pair
- 3) A super-sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair
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